Chinese researchers have developed a model to predict the degree of human organ aging, including the brain, enabling a precise assessment of aging levels in each organ. Previous research primarily focused on common traits of systemic aging or on aging mechanisms in isolated organs, making it difficult to decipher the unique genetic patterns and molecular pathways associated with the aging of different organs. This limitation hindered a deeper understanding of the nature of aging and restricted the development and implementation of precise strategies to combat it. The study, published in the 'China Daily' newspaper, specifically selected 554 genes susceptible to organ aging, whose functions show a high degree of compatibility with the physiological characteristics of the relevant organs, revealing the fundamental molecular mechanisms behind the aging process in each organ. The new model demonstrates strong and accurate predictive capabilities for assessing the state of organ aging across diverse population groups, laying the foundation for future mechanistic research and clinical applications. The new model facilitates early screening for high-risk groups, clarifies the causal relationships between organ aging and chronic diseases, and also reveals the impact of smoking on the aging of specific organs, providing crucial insights and evidence for disease prevention.
